Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to <i>In Vivo</i> Compatibility in a Murine Subdermal Implant Model

A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C3MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained simple water-in-oil gelation method using thiol–ene coupling investigated biocompatibility these hydrogel spheres 28-day murine subdermal model. For comparison, prepared poly(ethylene glycol) were also implanted. Both materials displayed mild, yet typical foreign body responses little signs fibrosis. This is first report response poly(2-oxazoline) hydrogel, which paves way for future investigations into how this tailorable class used implantable devices.